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Nausea and vomiting in pregnancy, often known as morning sickness, is very common in early pregnancy. It can affect you at any time of the day or night or you may feel sick all day long. Morning sickness is unpleasant, and can significantly affect your day-to-day life. But it usually clears up by weeks 16 to 20 of your pregnancy and does not put your baby at any increased risk. There is a chance of developing a severe form of pregnancy sickness called hyperemesis gravidarum. This can be serious, and there's a chance you may not get enough fluids in your body (dehydration) or not get enough nutrients from your diet (malnourishment). You may need specialist treatment, sometimes in hospital. Sometimes urinary tract infections (UTIs) can also cause nausea and vomiting. A UTI usually affects the bladder, but can spread to the kidneys. you're vomiting and: Unfortunately, there's no hard and fast treatment that will work for everyone’s morning sickness. Every pregnancy will be different. But there are some changes you can make to your diet and daily life to try to ease the symptoms. If these do not work for you or you're having more severe symptoms, your doctor or midwife might recommend medicine. Things you can try yourselfIf your morning sickness is not too bad, your GP or midwife will initially recommend you try some lifestyle changes:
Find out more about vitamins and supplements in pregnancy Anti-sickness medicineIf your nausea and vomiting is severe and does not improve after trying the above lifestyle changes, your GP may recommend a short-term course of an anti-sickness medicine, called an antiemetic, that's safe to use in pregnancy. Often this will be a type of antihistamine, which are usually used to treat allergies but also work as medicines to stop sickness (antiemetic). Antiemetics will usually be given as tablets for you to swallow. But if you cannot keep these down, your doctor may suggest an injection or a type of medicine that's inserted into your bottom (suppository). See your GP if you'd like to talk about getting anti-sickness medication. It's thought hormonal changes in the first 12 weeks of pregnancy are probably one of the causes of morning sickness. But you may be more at risk of it if:
Visit the pregnancy sickness support site for tips for you and your partner on dealing with morning sickness. Find maternity services near you Sign up for Start4Life's weekly emails for expert advice, videos and tips on pregnancy, birth and beyond.
In this video, a midwife gives advice on how to deal with morning sickness during your pregnancy.
Page last reviewed: 13 April 2021
Nausea and vomiting are common in pregnancy, particularly in the first trimester, with the severity varying greatly among pregnant women. A range of non-pharmacological and pharmacological interventions can be used to assist in managing nausea and vomiting in pregnancy. Women may find these interventions useful, although the evidence for their effectiveness remains inconclusive. 54.1 BackgroundNausea and vomiting in pregnancy ranges from mild discomfort to significant morbidity (King & Murphy 2009). Symptoms generally start around 4–9 weeks of pregnancy (Gadsby et al 1993). Nausea and vomiting due to other conditions (eg gastrointestinal, metabolic, neurologic or genitourinary) should always be excluded, particularly in women who report nausea or vomiting for the first time after 10 weeks (Koch & Frissora 2003). The most severe form of nausea and vomiting in pregnancy is Hyperemesis gravidarum, which is intractable vomiting in early pregnancy, leading to dehydration and ketonuria severe enough to justify hospital admission and intravenous fluid therapy (Bottomley & Bourne 2009). The cause of nausea and vomiting in pregnancy is not known but is probably multifactorial (Ebrahimi et al 2010). The rise in human chorionic gonadotrophin during pregnancy has been implicated; however, data about its association with nausea and vomiting are conflicting (Weigel & Weigel 1989). 54.1.1 Nausea and vomiting in pregnancy
54.1.2 Impact of nausea and vomiting in pregnancyAlthough distressing and debilitating for some women, nausea and vomiting do not appear to have a negative impact on pregnancy outcomes. A systematic review of observational studies found a reduced risk of miscarriage associated with nausea and vomiting (OR 0.36; 95%CI 0.32 to 0.42) and conflicting data regarding reduced risk for perinatal mortality (Weigel & Weigel 1989). No studies have reported an association between nausea and vomiting in pregnancy and teratogenicity (Klebanoff & Mills 1986). However, despite reassurance that nausea and vomiting do not have harmful effects on pregnancy outcomes, these symptoms can have a severe impact on a pregnant woman’s quality of life. Two observational studies have reported on the detrimental impact that nausea and vomiting may have on women’s day-to-day activities, relationships, use of healthcare resources and need for time off work (Smith et al 2000; Attard et al 2002). 54.2 Managing nausea and vomiting in pregnancyThe systematic review conducted to inform these Guidelines identified additional evidence that was consistent with the NICE guidelines. The highest quality study, a Cochrane review (Matthews et al 2010) examined 27 trials of interventions including acustimulation, acupuncture, ginger, vitamin B6 and several antiemetic medicines. Systematic review of studies in this area is complicated by the heterogeneity of studies and limited information on outcomes (Matthews et al 2010). The available evidence suggests the following:
It is currently not possible to identify with certainty interventions for nausea and vomiting in early pregnancy that are both safe and effective (Matthews et al 2010). As nausea and vomiting mostly resolves within 16 to 20 weeks with no harm to the pregnancy, prescribed treatment in the first trimester is usually not indicated unless the symptoms are severe and debilitating (BMA 2003).
54.2.1 Discontinuing ironIron supplementation may be an aggravating factor in nausea and vomiting. The systematic review conducted for these Guidelines identified a prospective cohort study (Gill et al 2009) in which 63 of 97 (p=0.001) women with severe nausea qualitatively reported an improvement in symptoms after discontinuing iron-containing antenatal multivitamins. If multivitamins are discontinued, consideration should be given to ensuring folate and iodine intake remain sufficient.
54.2.2 Oral healthNausea and vomiting have the potential to affect oral health and women should be given advice on how to minimise these effects (see Chapter 16). 54.3 Practice summary: managing nausea and vomitingWhenAt the first contact with all women and at subsequent contacts for women who report nausea and vomiting. Who
What
54.4 ResourcesReferences
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