What is the difference between partial and focal seizures?

February 3, 2022

Do you know the difference between focal and generalized onset seizures? Read our overview and understand how they affect the brain.

Has your doctor spoken to you about ‘focal onset’ or ‘generalized onset’ seizures? Physicians use these words to describe where in the brain a seizure started – but medical terms are often confusing!

So, here’s everything you need to know about the difference between generalized and focal seizures.

Focal vs generalized seizures

Seizures happen because of electrical discharges in the brain. When treating your seizures, doctors try to find out where in your brain abnormal electrical patterns start happening (this is known as ‘onset’). If they can find out, it might affect the kind of treatment they offer. The electrical patterns are also called discharges and can happen in two ways: generalized and focal. 

What is a generalized seizure?

This is when the electrical discharge happens in many different parts (both sides) of the brain and starts at the same time. About 40% of people with epilepsy have generalized onset seizures. 

Types of generalized seizure include:

  • Absence seizures (staring spells)
  • Atonic seizures (when your muscles go limp suddenly and you may fall over)
  • Myoclonic seizures (these are sudden jerks in your muscles)
  • Tonic clonic seizures (where you fall to the ground then shake)

What causes a focal seizure?

With a focal seizure, the electrical discharge starts in only one side of the brain and may stay there. But focal seizures sometimes spread to the whole brain and this is called a secondary generalized seizure. About 60% of people with epilepsy experience focal onset seizures. 

Types of focal seizure include:

  • Focal aware (when you understand what’s happening but cannot control it)
  • Focal impaired awareness (you are confused or not conscious of what’s happening)
  • Focal motor seizures (you will twitch and jerk a little, or walk around aimlessly)
  • Focal non-motor (you won’t move, but instead have intense feelings and emotions such as hot and cold, fear, or a rising stomach)

Depending on whether you have a generalized or focal onset seizure, what you experience before, during and after a seizure may be different.

Introduction to… Absence seizures‍

While the symptoms are different, the phases of generalized seizures and focal seizures are the same:

  1. Beginning phase (prodrome)

You may notice mood changes or an ‘aura’ which tells you a seizure is coming soon

This is when intense electrical activity happens in the brain and symptoms of seizures occur

This is the recovery stage, where you experience the aftereffects of having a seizures, such as tiredness, frustration, sickness and confusion

Keep learning: What happens in your brain during a seizure?

Diagnosing focal vs generalized seizures

When you are first diagnosed with epilepsy, your treatment team will want to work out if you have focal or generalized seizures. This information will help them decide which treatment plan is best for you. 

For example, the drugs carbamazepine and lamotrigine are often used to treat focal seizures, while sodium valproate is often used for generalized tonic-clonic seizures. 

To work out if you have focal or generalized onset seizures, the treatment team may use an EEG, an MRI or visual observation. It can also be helpful to ask someone who’s seen your seizures to record a video or provide a detailed description. This might help identify the type of seizures you have. 

Focal vs generalized seizures is the main division of seizures types. But within each of these two categories there are many other types of seizure and epilepsy syndrome. Learn more about specific types of seizures and syndrome in our blogs. 

There are several different types of seizures. Most seizures can be categorized as either focal or generalized.

1. Focal (or partial) seizuresExpand 1. Focal (or partial) seizures Section

Focal (or partial) seizures occur when seizure activity is limited to a part of one brain hemisphere. There is a site, or a focus, in the brain where the seizure begins. There are two types of focal seizures:

If you have epilepsy, ask your healthcare provider to explain what type of seizures you have. Learning the names and terms for your seizure type(s) can help you describe it accurately to others.

2. Generalized SeizuresExpand 2. Generalized Seizures Section

Generalized seizures occur when there is widespread seizure activity in the left and right hemispheres of the brain. The different types of generalized seizures are:

Additional Seizure TypesExpand Additional Seizure Types Section

Infantile Spasms
Infantile spasms are a type of epilepsy seizure but they do not fit into the category of focal or generalized seizures.

Psychogenic Non-epileptic Seizures (PNES)
Psychogenic non-epileptic seizures are not due to epilepsy but may look very similar to an epilepsy seizure.

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Focal seizures are a type of seizure that affects only one side of your brain and body. These seizures tend to be less severe than generalized seizures, which affect both sides of your brain and body. Focal seizures are the most common type of seizures with epilepsy, and are often seen with conditions like stroke, head injuries and more.

Focal Seizure

Focal seizures — formerly known as partial seizures — are seizures that happen in specific parts of your brain. Focal seizure symptoms reflect the region of brain from which they originate.

The initial symptoms of focal seizures may involve odd experiences during which time awareness is maintained. However, if the seizures continue to spread to other regions of your brain, they can sometimes progress to a loss of awareness (tonic-clonic seizures).

What is the difference between focal seizures vs. generalized seizures?

A seizure is an uncontrolled surge of electrical activity in your brain. That surge causes affected brain cells (neurons) to send signals to other neurons around them. The symptoms of seizures depend on where they happen in your brain.

Your brain has left and right halves, known as hemispheres. Generalized seizures affect both hemispheres of your brain, causing symptoms that affect both sides of your body. These are usually more severe.

Focal seizures begin in one location within your brain — in either the right or left hemisphere. As the seizure intensifies, the surge of electrical activity can move from one location to another and eventually even cross from one brain hemisphere to another. In some instances, a focal seizure can progress to a “generalized tonic-clonic seizure.” Today, healthcare providers call these seizures “focal to bilateral tonic-clonic seizures”.

NOTE: Seizures and epilepsy aren’t the same thing, either. For more general information, including the difference between seizures and epilepsy, see our main seizure article.

Who does it affect?

Anyone can have seizures under the right circumstances. However, focal seizures can happen more easily if you have certain brain conditions. Focal seizures are most common in people who have head injuries, birth abnormalities of their brain, febrile seizures in childhood, infections of their brain (encephalitis), strokes, brain tumors or other conditions that affect their brain.

How common are focal seizures?

Focal seizures are the most common type of seizure, making up more than half of all seizures. One specific type of seizure, focal (impaired awareness), makes up just over one-third of all seizures.

How does this condition affect my body?

The symptoms that occur during a focal seizure depend on where in your brain the seizure happens. Symptoms that can arise from a focal seizure are described below. It is important to control focal seizures because over time they can lead to memory problems or issues with thinking ability. They can also increase your risk for some mood disorders like depression and anxiety.

Some people with focal seizures can experience an aura. Auras can be the initial symptoms of a focal seizure. Auras occur while you're still aware, and during this time you can experience a wide variety of symptoms. When focal seizures don’t spread, an aura can be the only manifestation of the seizure.

Auras can take many different forms. These include:

  • Sensory symptoms.
  • Emotional changes.
  • Autonomic symptoms.

Auras don’t happen in people with generalized epilepsy. Their presence suggests a diagnosis of focal epilepsy. When an aura from a focal seizure happens, it can sometimes be a warning sign for people, as auras can evolve into a seizure with a loss of awareness.

What are the other symptoms of focal seizures?

Focal seizure symptoms depend on the type of seizure and its location in your brain. There are three main kinds of focal seizures:

  • Focal aware seizures: Sometimes known as simple focal seizures or simple partial seizures, the key feature of these seizures is that you’re aware of them when they happen. Auras that happen with these are the seizure itself.
  • Focal impaired awareness seizures: These are sometimes known as complex partial seizures or complex focal seizures. These disrupt your awareness of what’s happening. If you have an aura, it will happen before any disruption in your awareness. These usually last no more than three minutes. About 36% of all seizures are this type, making them the most common of all seizures.
  • Focal to bilateral tonic-clonic seizure: These used to be called generalized tonic-clonic seizures. These seizures involve full body muscle movements and convulsions.

Focal seizure symptoms fall into four different groups, and a seizure can involve more than one of these groups. The groups are:

  • Motor.
  • Sensory.
  • Autonomic.
  • Cognitive.

Focal motor symptoms

Seizures with motor effects cause unconscious or involuntary movements. These often affect your face, hands and toes on one side. They can involve twitching or jerking muscle movements, uncontrolled tightening up of muscles, or repetitive/automatic movements (smacking your lips, blinking or tapping a hand or finger).

Focal motor symptoms can also spread across an affected body part and to other parts of your body. The name for this effect is “Jacksonian march.” These seizures start in a small area and then "march" to the entire body part, and often continue onto other body parts or the face on the same side.

After focal motor symptoms happen, many people have paralysis in their affected body parts. Known as “Todd paralysis,” this is a temporary effect, but it can last several hours. Telling your healthcare provider about this can help with diagnosing and treating seizures.

Focal sensory symptoms

If an aura affects neurons in parts of your brain connected to your senses, the neurons can mistakenly act like they’re getting real input. That can make you think something is happening when it really isn’t. These kinds of symptoms, known as hallucinations, can affect all five of your senses. Examples include:

  • Visual: Seeing bright lights, flashes or distortions in how objects look (they appear bigger or smaller).
  • Hearing: Hearing unexpected or non-specific sounds and noises.
  • Smell: Smelling something that isn’t there; usually happens suddenly and unexpectedly.
  • Taste: Also usually sudden and unexpected; these are often non-specific, like something metallic, sour or bitter.
  • Touch: Strange feelings on or underneath your skin in a specific body part; may feel like pins and needles, tingling or crawling, or even heat or pain.

It’s important to describe any sensory symptoms and hallucinations to your provider as best you can. Knowing about the affected sense(s) can help providers locate where a seizure happened in your brain.

Focal autonomic symptoms

Auras can affect body systems that your brain runs automatically. Some examples include:

  • Sweating.
  • Making too much saliva or drooling.
  • Skin color changes (going pale or turning red).
  • “Gastric uprising," which is a rising feeling in your belly.

Focal cognitive symptoms

Auras cause changes in your emotional state. Examples of this include:

  • Negative emotions: Fear, anxiety, agitation or anger.
  • Positive emotions: Joy, excitement or uncontrollable laughter.
  • Disruptions in reality: Dream-like feelings or flashbacks. Some people describe feeling like they have special powers or talking to a higher power.
  • Déjá vu (“day-zha voo”): A French term for when a new experience somehow feels familiar.
  • Jamais vu (“zha-may voo”): Also French, when a familiar experience that somehow feels new.

Other cognitive changes that occur in focal seizures include changes in level of awareness, changes to memory, changes to your language function or ability to communicate and impairment to interact with your environment appropriately.

What causes focal seizures?

Focal seizures can happen for many reasons, including the following:

  • Aneurysms.
  • Irregular heart rhythms (arrhythmias).
  • Brain tumors (including cancer).
  • Cerebral hypoxia (lack of oxygen).
  • Concussion and traumatic brain injury.
  • Degenerative brain diseases like Alzheimer’s disease or frontotemporal dementia.
  • Drug or alcohol withdrawal.
  • Eclampsia, (a condition that causes high blood pressure in people who are pregnant).
  • Electrolyte problems, especially low sodium (hyponatremia), calcium or magnesium.
  • Fevers, especially high ones (known as febrile seizures).
  • Genetic disorders (conditions you inherit from one or both parents).
  • Hormone-related changes (catamenial epilepsy can affect people with a menstrual cycle, making seizures more likely at certain points in the cycle).
  • Infections (especially encephalitis or meningitis, which can happen because of viruses, bacteria, parasites, etc.).
  • Inflammation from immune system disorders.
  • Insomnia and other sleep-related problems.
  • Metabolic problems, especially high blood sugar (hyperglycemia) or low blood sugar (hypoglycemia).
  • Problems with your brain structure (especially ones you have at birth).
  • Sepsis (a life-threatening overreaction of your immune system to an infection spreading throughout your body).
  • Strokes or transient ischemic attacks (TIAs).
  • Using drugs and alcohol (including prescription medications, recreational drugs and even caffeine).

Are focal seizures contagious?

No, focal seizures aren't contagious. However, some conditions that cause focal seizures are genetic (you can inherit them from your parents, or your children can inherit them from you).

A healthcare provider, usually a neurologist, can diagnose focal seizures based on the symptoms you had (or that others describe) and diagnostic tests. These tests can usually confirm if you had a seizure and whether it was provoked or unprovoked. Genetic tests can also uncover inherited conditions that cause seizures.

A key part of diagnosing focal seizures is finding the focal point, a specific area where the seizure(s) started. Locating the focal point can greatly help with treating focal seizures.

What tests will be done to diagnose this condition?

Possible tests with seizures include:

  • Blood tests (these look for metabolic and blood chemistry imbalances, immune system problems, toxins and poisons and check levels of antiseizure medications).
  • Electroencephalogram (EEG).
  • Video-EEG monitoring.
  • Magnetic resonance imaging (MRI).
  • Positron emission tomography (PET) scan.
  • Ictal single-photon emission computed tomography (SPECT).
  • Magnetoencephalography (MEG).
  • Intracranial EEG monitoring with subdural electrodes, depth electrodes or Stereo-EEG (SEEG).
  • Spinal tap (lumbar puncture), when your provider is concerned that the epilepsy is caused by an infection or immunologic brain disease (a disease where your body’s own immune system attacks various parts of the brain).

Providers might also recommend other tests to determine if you have any kind of injury, side effects or complications from a seizure. Your healthcare provider is the best person to tell you (or someone you choose to make medical decisions for you) what kind of tests they recommend and why.

Diagnosing and treating focal seizures starts with finding out if they're provoked or unprovoked. When possible, treating the underlying cause of provoked seizures can often stop seizures from happening. If the underlying cause isn't treatable, healthcare providers will usually try to treat the seizures, so they are less severe or happen less often.

Providers usually recommend against treating first-time unprovoked seizures unless you have a high risk of having another. If you have a high risk or have had an unprovoked seizure before, they'll likely diagnose you with epilepsy and recommend starting treatment.

What medications or treatments are used?

The treatments for focal seizures vary widely. For provoked seizures, the treatments almost always depend on the cause. The treatments for unprovoked and epilepsy-related seizures depend on the type(s) of seizures, why they are happening and which treatments work best.

Possible treatments for seizures due to epilepsy include:

  • Medications. Different medications can stop seizures as they happen, and other kinds can prevent seizures or make them happen less often. Some are intravenous (IV) medications to treat seizures as they happen. Others are a pill you take daily.
  • Diet changes. Low- or no-carb (ketogenic) diets can sometimes stop epileptic seizures entirely or reduce how often they happen.
  • Epilepsy surgery. Surgery can sometimes stop seizures by removing or disconnecting the problem area from the rest of the brain.
  • Vagal nerve stimulation (VNS). Electrical stimulation of your vagus nerve, which connects directly to your brain, on its left side can help reduce how often seizures happen.
  • Responsive Neurostimulation (RNS). This is a system whereby a device detects ongoing epileptic activity in your brain and delivers electrical stimulation directly to the region of your brain generating the epileptic activity. The RNS device can lower your seizures over long periods of time.
  • Deep brain stimulation (DBS). This treatment uses a device implanted into your body with wires connected to specific parts of your brain. The device delivers a mild electrical current, which interferes with the electrical malfunctions that happen with seizures.

The possible complications with seizure treatments depend on the cause, type of seizure and more. Your healthcare provider is the best person to tell you what you can or should expect. That's because they can give you relevant information about your specific case.

How to take care of myself/manage symptoms?

You shouldn’t try to self-diagnose or treat a focal seizure, since seizures are often a sign of serious brain conditions. If you or a loved one have a first-time seizure, see a healthcare provider as soon as possible. If you have epilepsy, your healthcare provider can tell you which symptoms or effects mean you need medical care.

How soon after treatment will I feel better?

Recovery time depends on the types of seizures you have and the treatments you receive. Your healthcare provider can tell you what to expect, including how long it will take you to recover and when you should feel better.

Everyone is at risk for seizures, and they also happen unpredictably, so it’s not possible to prevent them. The best thing you can do is avoid possible causes to reduce the chances of having a seizure.

Some important steps you can take to reduce your risk of having a seizure include:

  • Eat a balanced diet and maintain a healthy weight. Many conditions related to your circulatory and heart health can damage areas of your brain. Stroke and related conditions are very commonly connected to focal seizures.
  • Don’t ignore infections. Eye and ear infections need timely treatment. If these infections spread to your brain, they can cause seizures. Infections can also cause high fevers, which can lead to seizures.
  • Wear safety equipment. Head injuries are a major cause of focal seizures. Using safety equipment whenever necessary can help you avoid brain damage that could cause a focal seizure or make it easier to have them in the future. Examples of safety gear include helmets and seat belts (or other vehicle safety restraints).
  • Manage your health conditions. Managing chronic conditions can help you avoid seizures, especially those that happen because of your blood sugar with either Type 1 diabetes or Type 2 diabetes.

Many people who have a first focal seizure go on to have unprovoked focal seizures. So, it’s important to talk to your healthcare provider so that they can diagnose the condition and recommend further treatment. Some patients with focal epilepsy may go on to develop “drug-resistant or medically refractory epilepsy.” This means that medications don’t do enough to help. Drug-resistant epilepsy is often treatable with surgery. Be sure to seek guidance from a provider with expertise in epilepsy surgery.

How long will I have this condition?

For provoked seizures, your risk of having another depends on why you had the first one. If the cause was treatable or curable, it’s likely you won’t have another (unless the same cause happens again).

For unprovoked seizures, the vast majority will come under control with an appropriate antiseizure medication. However, if focal seizures continue, it’s important to seek care at an epilepsy center. It’s possible for epilepsy to go into remission and for you to remain seizure-free for the rest of your life.

What’s the outlook for this condition?

The outlook for focal seizures and epilepsy depends on the cause, severity and if antiseizure medications help. Overall, focal seizures aren't dangerous, but they can turn into tonic-clonic seizures that are dangerous if they last too long or happen too often.

For the most part, focal seizures have a positive outlook with medications or surgery.

Your healthcare provider is the best person to tell you more about the outlook and what you can expect with seizures and epilepsy. They can provide information relevant to your condition and situation and guide you on what you can do to help yourself with these conditions.

Sudden unexpected death in epilepsy

There's a small risk of sudden unexpected death in epilepsy (SUDEP) for people with this condition. Experts suspect SUDEP happens because of heart rhythm malfunctions or breathing problems, but the actual cause is unknown.

For people with controlled (treated) epilepsy, the death rate each year is about 1 person out of every 1,000. For people with uncontrolled (poorly treated) epilepsy, the death rate each year is about 2 out of every 1000 per year.

If you've had one focal seizure in the past, it's important to seek medical advice so that appropriate tests can be done. If you have continued seizures, it’s extremely important that you seek care from an epilepsy center that has expertise in advanced testing for people with uncontrolled epilepsy. This is because, over time, seizures can cause changes in your brain that make it easier for more seizures to happen and affect how well you think and remember things. In addition, uncontrolled seizures are linked to a higher chance of other brain conditions like depression and anxiety. Early diagnosis and treatment can help with that.

If a healthcare provider diagnoses you with epilepsy, you can still do the following to help yourself:

  • Take your medication as prescribed. Anti-epilepsy medications can reduce how often you have seizures and how severe they are. Because of that, taking your medications as prescribed is critical. The only time you should stop your medications is with guidance and monitoring from your healthcare provider.
  • Talk to your provider about alternatives. If you want to try tapering off or switching your medications, your healthcare provider can guide you on whether or not this process is likely to work and how to do it safely.
  • See your provider as recommended. Your healthcare provider will schedule follow-up visits. These visits are vital because they allow your provider to monitor your condition, adjust your medication, etc.
  • Don’t ignore or avoid symptoms. The outlook for seizures and epilepsy is usually better with early diagnosis and treatment.

When should I go to the ER?

If you’ve never had a seizure before, you should go to the hospital if you pass out unexpectedly or for an unknown reason. If you’re alone and think you’ve had a seizure, contact your healthcare provider as soon as possible.

For people who have epilepsy, it’s often not necessary to call an ambulance or go to the hospital after a seizure. However, they might still need medical care or treatment for seizure-related injuries or prolonged seizures (seizures lasting more than two minutes).

A note from Cleveland Clinic

Focal seizures can cause a wide range of symptoms, many of which are confusing or scary if you’ve never experienced them before. These seizures also happen often in children, which can be frightening for children and parents alike. However, focal seizures and epilepsy are often treatable. In many cases, children with focal epilepsy will outgrow the condition and remain seizure-free for the rest of their lives. Adults also commonly live with focal seizures and epilepsy, and with treatment and care, many can live their lives with minimal effects from their condition.

Last reviewed by a Cleveland Clinic medical professional on 04/29/2022.

References

  • Aeby A, Ceulemans B, Lagae L. Treatment of Focal-Onset Seizures in Children: Should This Be More Etiology-Driven? (//pubmed.ncbi.nlm.nih.gov/35330806/) Front Neurol. 2022;13:842276. Published 2022 Mar 7. Accessed 4/29/2022.
  • Amrutkar C, Riel-Romero RM. Rolandic Epilepsy Seizure. (//www.ncbi.nlm.nih.gov/books/NBK534845/) [Updated 2021 Aug 11]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Accessed 4/29/2022.
  • Beghi E. The Epidemiology of Epilepsy. (//pubmed.ncbi.nlm.nih.gov/31852003/) Neuroepidemiology. 2020;54(2):185-191. Chapter 15: Epilepsy and Other Seizure Disorders. In: Ropper AH, Samuels MA, Klein JP, Prasad S. eds. Adams and Victor's Principles of Neurology, 11e. McGraw Hill; 2019. Accessed 4/29/2022.
  • Emmady PD, M Das J. Benign Occipital Seizure. (//www.ncbi.nlm.nih.gov/books/NBK557470/) [Updated 2021 Jul 6]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Accessed 4/29/2022.
  • Genetic and Rare Diseases Information Center | rarediseases.info.nih.gov. Benign rolandic epilepsy. (//rarediseases.info.nih.gov/diseases/10287/benign-rolandic-epilepsy-bre) Updated 2018 June 4. Accessed 4/29/2022.
  • Kumar A, Maini K, Arya K, et al. Simple Partial Seizure. (//www.ncbi.nlm.nih.gov/books/NBK500005/) [Updated 2021 Dec 17]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Accessed 4/29/2022.
  • Kumar A, Sharma S. Complex Partial Seizure. (//www.ncbi.nlm.nih.gov/books/NBK519030/) [Updated 2021 Jun 29]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Accessed 4/29/2022.
  • Patel PR, De Jesus O. Partial Epilepsy. (//www.ncbi.nlm.nih.gov/books/NBK564376/) [Updated 2022 Feb 13]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Accessed 4/29/2022.
  • Rao VR, Lowenstein DH. Seizures and Epilepsy. In: Loscalzo J, Fauci A, Kasper D, Hauser S, Longo D, Jameson J. eds. Harrison's Principles of Internal Medicine 21e. McGraw Hill; 2022. Accessed 4/29/2022.

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