A nurse is talking about the hormone that has the opposite physiologic effects of insulin

There are a few ways that exercise lowers blood sugar:

  • Insulin sensitivity is increased, so your muscle cells are better able to use any available insulin to take up glucose during and after activity.
  • When your muscles contract during activity, your cells are able to take up glucose and use it for energy whether insulin is available or not.

This is how exercise can help lower blood sugar in the short term. And when you are active on a regular basis, it can also lower your A1C.

Understanding Your Blood Sugar and Exercise

The effect physical activity has on your blood sugar will vary depending on how long you are active and many other factors.  Physical activity can lower your blood sugar up to 24 hours or more after your workout by making your body more sensitive to insulin.

Become familiar with how your blood sugar responds to exercise. Checking your blood sugar level more often before and after exercise can help you see the benefits of activity. You also can use the results of your blood sugar checks to see how your body reacts to different activities. Understanding these patterns can help you prevent your blood sugar from going too high or too low.

Hypoglycemia and Physical Activity

People taking insulin or insulin secretagogues (oral diabetes pills that cause your pancreas to make more insulin) are at risk for hypoglycemia if insulin dose or carbohydrate intake is not adjusted with exercise. Checking your blood sugar before doing any physical activity is important to prevent hypoglycemia (low blood sugar).  Talk to your diabetes care team (doctor, nurse, dietitian or pharmacist) to find out if you are at risk for hypoglycemia.

If you experience hypoglycemia during or after exercise, treat it immediately:

Follow the 15-15 rule:

1. Check your blood sugar.

2. If your reading is 100 mg/dL or lower, have 15-20 grams of carbohydrate to raise your blood sugar. This may be:

  •     4 glucose tablets (4 grams per tablet), or
  •     1 glucose gel tube (15 grams per gel tube), or
  •     4 ounces (1/2 cup) of juice or regular soda (not diet), or
  •     1 tablespoon of sugar or honey

3. Check your blood sugar again after 15 minutes. If it is still below 100 mg/dL, have another serving of 15 grams of carbohydrate.

4. Repeat these steps every 15 minutes until your blood sugar is at least 100 mg/dL.

If you want to continue your workout, you will usually need to take a break to treat your low blood sugar. Check to make sure your blood sugar has come back up above 100 mg/dl before starting to exercise again.

Keep in mind that low blood sugar can occur during or long after physical activity. It is more likely to occur if you:

  • Take insulin or an insulin secretagogue
  • Skip meals 
  • Exercise for a long time
  • Exercise strenuously

If hypoglycemia interferes with your exercise routine, talk to your healthcare provider about the best treatment plan for you. Your provider may suggest eating a small snack before you exercise or they may make an adjustment to your medication(s). For people engaging in long duration exercise, a combination of these two regimen changes may be necessary to prevent hypoglycemia during and after exercise.

Medically reviewed by Alan Carter, Pharm.D.Written by Zawn Villines on March 27, 2019

The pancreas secretes insulin and glucagon. Both hormones work in balance to play a vital role in regulating blood sugar levels. If the level of one hormone is higher or lower than the ideal range, blood sugar levels may spike or drop.

Together, insulin and glucagon help maintain a state called homeostasis in which conditions inside the body remain steady. When blood sugar is too high, the pancreas secretes more insulin. When blood sugar levels drop, the pancreas releases glucagon to raise them.

This balance helps provide sufficient energy to the cells while preventing the nerve damage that can result from consistently high levels of blood sugar.

In this article, we explain the functions and processes of insulin and glucagon as well as their effects on diabetes.

The body converts the carbohydrates from food into glucose, a simple sugar that serves as a vital source of energy.

Blood sugar levels are a measure of how effectively the body uses glucose.

These vary throughout the day. However, in most instances, insulin and glucagon keep these levels within a healthy range.

When the body does not convert enough glucose, blood sugar levels remain high. Insulin helps the cells absorb glucose, reducing blood sugar and providing the cells with glucose for energy.

When blood sugar levels are too low, the pancreas releases glucagon. Glucagon instructs the liver to release stored glucose, which causes blood sugar to rise.

Islet cells in the pancreas are responsible for releasing both insulin and glucagon. The pancreas contains many clusters of these cells. There are several different types of islet cell, including beta cells, which release insulin, and alpha cells, which release glucagon.

How insulin works

The cells need glucose for energy. However, most of them are unable to use glucose without the help of insulin.

Insulin gives glucose access to the cells. It attaches to the insulin receptors on cells throughout the body, instructing the cells to open up and grant entry to glucose.

Low levels of insulin constantly circulate throughout the body. A spike in insulin signals to the liver that blood glucose is also high. The liver absorbs glucose then changes it into a storage molecule called glycogen.

When blood sugar levels drop, glucagon instructs the liver to convert the glycogen back to glucose, causing blood sugar levels to return to normal.

Insulin also supports healing after an injury by delivering amino acids to the muscles. Amino acids help build the protein that is present in muscle tissue, so when insulin levels are low, muscles may not heal properly.

How glucagon works

The liver stores glucose to power the cells during periods of low blood sugar. Skipping meals and poor nutrition can lower blood sugar. By storing glucose, the liver makes sure that blood glucose levels remain steady between meals and during sleep.

When blood glucose falls, cells in the pancreas secrete glucagon. Glucagon instructs the liver to convert glycogen to glucose, making glucose more available in the bloodstream.

From there, insulin attaches to its receptors on the body’s cells and ensures that they can absorb glucose.

Insulin and glucagon work in a cycle. Glucagon interacts with the liver to increase blood sugar, while insulin reduces blood sugar by helping the cells use glucose.

A range of factors, including insulin resistance, diabetes, and an unbalanced diet, can cause blood sugar levels to spike or plummet.

The standard measurement units for blood sugar levels are milligrams per deciliter (mg/dl). Ideal blood sugar ranges are as follows:

TimingBlood glucose level (mg/dL)
Before breakfastPerson without diabetes: 100 mg/dL
Person with diabetes: 70–13
2 hours after a mealPerson without diabetes: Less than 140 mg/dL
Person with diabetes: Less than 180 mg/dL
BedtimePerson without diabetes: 120 mg/dL
Person with diabetes: 90–150 mg/dL

A1C is a measurement that gives a picture of average glucose levels over an extended period. A1C readings should be under 7 percent for people with diabetes and less than 6 percent for those without diabetes.

Read more about optimal blood sugar levels by clicking here.

Insulin and glucagon do not take immediate effect, particularly in people whose blood sugar levels are extremely high or low.

High blood sugar

Share on PinterestDiabetes can cause itching.

The symptoms of high blood sugar include:

  • Urinating more often than usual: The kidneys respond to high blood sugar by trying to get rid of excess glucose.
  • Excessive thirst that accompanies frequent urination: The kidneys can cause dehydration and feelings of intense thirst when trying to regulate blood sugar.
  • Feeling excessively hungry: High blood sugar does not directly cause feelings of hunger. However, a drop in insulin often causes hunger when it accompanies high blood sugar.

Over time, extremely high blood sugar may lead to the following symptoms:

Low blood sugar

Delays between meals, poor nutrition, some diabetes medications, and certain medical conditions can cause low blood sugar.

The symptoms of low blood sugar include:

  • dizziness
  • rapid heartbeat
  • weakness
  • tingling, particularly in the tongue, lips, arms, or legs
  • hunger alongside nausea
  • fainting
  • confusion and difficulty concentrating
  • irritability

Without treatment, low blood sugar can lead to seizures or loss of consciousness.

Diabetes develops either when insulin becomes ineffective or when the body cannot produce enough of it. The disease causes problems with blood sugar regulation.

There are several different types of diabetes:

Type 1 diabetes

Type 1 diabetes is an autoimmune condition that often presents at a young age. For this reason, it is sometimes called juvenile diabetes.

This type of diabetes involves attacks by the immune system on some of the insulin-secreting beta cells in the pancreas.

People with type 1 diabetes often experience very high blood sugar. Low insulin levels, however, mean that they cannot use much of the glucose in their blood.

Type 2 diabetes

Type 2 diabetes is the most common type of diabetes, and it usually develops due to lifestyle issues, such as being overweight.

People with type 2 diabetes have insulin resistance, which means that the cells do not respond properly when insulin instructs them to absorb glucose from the bloodstream.

Gestational diabetes

Share on PinterestDiabetes can develop in women who are pregnant.

Gestational diabetes is a form of diabetes that develops in some women during pregnancy.

When a woman is pregnant, the placenta that supports the developing baby might impair her body’s ability to use insulin.

The result of this is insulin resistance that triggers symptoms similar to those of type 2 diabetes.

Gestational diabetes usually goes away after the baby is born. However, it is a risk factor for the later development of type 2 diabetes.

Insulin and glucagon are vital for maintaining normal ranges of blood sugar.

Insulin allows the cells to absorb glucose from the blood, while glucagon triggers a release of stored glucose from the liver.

Everyone who has type 1 diabetes and some people with type 2 diabetes will need to supplement their insulin and manage their blood sugar through diet and regular exercise.

Last medically reviewed on March 27, 2019

  • Diabetes
  • Endocrinology
  • Nutrition / Diet
  • Obesity / Weight Loss / Fitness

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